Stock of the Day

December 10, 2019

Arrowhead Pharmaceuticals (ARWR)

$58.50
+$0.13 (+0.2%)
Market Cap: $8.22B

About Arrowhead Pharmaceuticals

Arrowhead Pharmaceuticals, Inc. develops medicines for the treatment of intractable diseases in the United States. The company's products in pipeline includes Plozasiran, which is in Phase 2b and one Phase 3 clinical trial to treat hypertriglyceridemia, mixed dyslipidemia, and chylomicronemia syndrome; Zodasiran that is in Phase 2b clinical trial for the treatment of dyslipidemia and hypertriglyceridemia; ARO-PNPLA3, which is in Phase 1 clinical trial to treat patients with non-alcoholic steatohepatitis; ARO-RAGE that is in Phase 1/2a clinical trial to treat inflammatory pulmonary conditions; and ARO-MUC5AC, which is in Phase 1/2a clinical trial to treat muco-obstructive pulmonary diseases. It also develops ARO-MMP7 that is in Phase 1/2a clinical trial for treatment of idiopathic pulmonary fibrosis; ARO-DUX4 for the treatment of facioscapulohumeral muscular dystrophy; ARO-SOD1 for the potential treatment of amyotrophic lateral sclerosis; and ARO-C3, which is in Phase 1/2a clinical trial for the treatment of patients with various complement mediated or complement associated renal diseases. In addition, the company is involved in the development of JNJ-3989, which is in Phase 2 clinical trial to treat chronic hepatitis B virus infection; Olpasiran that is in Phase 3 clinical trial to reduce the production of apolipoprotein A; GSK-4532990 that is in phase 2 clinical trial to treat liver diseases; HZN-457, which is in phase 1 clinical trial to treat uncontrolled gout; and Fazirsiran that is in Phase 3 clinical trial for the treatment for liver disease associated with alpha-1 antitrypsin deficiency. Arrowhead Pharmaceuticals, Inc. has license and research collaboration agreements with Janssen Pharmaceuticals, Inc.; Takeda Pharmaceutical Company Limited; Horizon Therapeutics Ireland DAC; Amgen Inc.; and Glaxosmithkline Intellectual Property (No. 3) Limited. The company was founded in 2003 and is headquartered in Pasadena, California.

Today's Trend

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) is attracting investor attention after reporting encouraging interim clinical data for ARO-MAPT, its investigational RNAi treatment for Alzheimer’s disease and other tauopathies. The results appear to be the primary catalyst supporting the stock’s recent strength.

  • Interim Phase 1/2a data showed ARO-MAPT crossed the blood-brain barrier and produced deep, durable tau reductions of up to 73% in healthy volunteers. Arrowhead said the results represent initial clinical validation of its TRiM™ CNS delivery platform, potentially expanding its ability to develop RNAi medicines for neurological diseases. Arrowhead ARO-MAPT interim clinical data
  • Coverage of the Alzheimer’s results emphasized the potential breakthrough of delivering gene-silencing medicine into the brain, while follow-up commentary described the findings as unlocking a broader platform for central nervous system diseases. ARWR interim ARO-MAPT data
  • Analyst sentiment remains strongly bullish: UBS initiated coverage with a Buy rating and a $109 price target, while Chardan Capital and HC Wainwright reaffirmed Buy ratings with targets of $115 and $120, respectively. These targets imply substantial potential upside if ARO-MAPT and the TRiM platform continue to progress. Arrowhead analyst ratings
  • The findings are interim and were generated in healthy volunteers, so they demonstrate target engagement and delivery rather than proof that ARO-MAPT improves Alzheimer’s symptoms or slows disease progression.
  • ARO-MAPT remains an investigational, early-stage program. Future trials will need to confirm safety, durability, clinical benefit, and commercial viability, leaving ARWR exposed to typical biotechnology development and regulatory risks.

Arrowhead Pharmaceuticals Shares Point North (NASDAQ: ARWR)

Written By Sam Quirke on 12/5/2019

Arrowhead Shares Point North (NASDAQ: ARWR)

Shares of Arrowhead Pharmaceuticals (NASDAQ: ARWR) changed hands in heavy trading on Wednesday after the company announced an equity offering before the market opened. Having reported earnings last week that smashed estimates and sent the stock to all-time highs, this was a nasty surprise to investors and a timely reminder of the risks inherent to biotech stocks.

Shares were down 8% in pre-market trading and gapped down even further on the open. However, they quickly caught a bid and finished the day near their session high.

There’s no doubt that many on Wall Street viewed the dip as a potentially great buying opportunity considering the quality of Arrowhead’s earnings last week.

The stock hit a 12 year high in the days following last Tuesday’s report as revenues soared an eye-watering 945% year on year. Amidst all the bottle popping though, it looked as if there was some significant profit-taking starting to set in. The stock gave up 15% on Monday and tested those lows again on Tuesday and Wednesday, but the strong close seen even in the face of the offering last evening bodes well for momentum.

Performance of recent years

Shares of the $6 billion biotech company have had an outstanding year so far and are up over 450% year to date. Even XBI, the benchmark biotech index, has only logged a 30% gain for 2019 so far.

Arrowhead’s shares were already buoyed going into the latest earnings report by a bullish upgrade from Baird. One of Arrowhead’s competitors in the growing field of RNAi technology, The Medicines Co. (NASDAQ:MDCO), was purchased by Novartis for $7 billion late last month and this seems to have put a very attractive spotlight on Arrowhead.

Coupled with the fact that much of Arrowhead’s drug pipeline has seen promising results and progress this year, big pharma is sure to be taking an interest in them and their investors know exactly what that could mean more than anyone.

Technical analysis

The stock has been a dream to trade for technical traders this year. It spent September cooling off from August’s highs but bounced sharply off a strong support line at $26 (which it tapped in July) to start October with a spring in its step. A bullish MACD crossover at the start of that month confirmed the buy and shares had already rallied 90% before last week’s upgrade and subsequent earnings doubled those gains.

However, this also meant RSI became super hot as it almost touched a reading of 90, indicating extremely overbought conditions. The pullback and consolidation we’ve seen since look like nothing more than a bit of steam being let off and there’s nothing unhealthy about that. The fact that shares were bought after the offering shows the internal momentum this stock has and just how attractive it is to Wall Street right now. Let’s see some continued consolidation in the coming sessions before a move up towards the $75 level and a resumption of ‘normal business’ for shares of this biotech leader.

Looking Ahead to Coming Weeks

It’s worth noting that aside from the technical qualities of the stock and it’s current momentum, there are one or two fundamental based red flags popping up. Arrowhead’s PE ratio of 90, in particular, has started to catch a little heat, with pressure shifting to management to keep exceeding quarterly expectations. It’s certainly a little rich compared to the industry average of 25 but all these exploratory companies are somewhat speculative and indeed, this is what attracts so many investors and so much attention.

If you’re interested in less volatile biotech and pharma names that are still worthy of being on your watchlist, check out our recently published article “Pharmaceutical Stocks - Best Pharmaceutical Stocks to Buy” and “Biotech Stocks - Best Biotech Stocks to Buy”.

For now though, with the S&P 500 at all-time highs, we’re certainly in a risk-on trading environment and there’s nothing more attractive in such a setting than promising biotech like Arrowhead that’s got incredible forward momentum.

Arrowhead Shares Point North (NASDAQ: ARWR)

Recent News