Stock of the Day

August 16, 2021

Axsome Therapeutics (AXSM)

$230.00
-$7.04 (-3.0%)
Market Cap: $12.20B

About Axsome Therapeutics

Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder; and Sunosi (solriamfetol), a medication indicated to the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea. It is also developing AXS-05, which is in Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation; AXS-07, an investigational medicine that has completed Phase III trials for the acute treatment of migraine; AXS-12, an investigational medicine, which is in Phase III trial to treat narcolepsy; AXS-14, a selective and potent norepinephrine reuptake inhibitor that has completed Phase III trial for the treatment of fibromyalgia and other conditions; and solriamfetol, a dual-acting dopamine and norepinephrine reuptake inhibitor, which has completed a Phase 2 trial for treating attention-deficit/hyperactivity disorder, and is in phase 2 major depressive, binge eating, and shift work disorder. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.

Today's Trend

Axsome Therapeutics, Inc. (NASDAQ: AXSM) shares have been under pressure as investors weigh a strong recent run-up against signs the valuation may be getting stretched. Several commentary pieces published today questioned whether the stock is now fully priced after its one-year surge, which can weigh on momentum buying.

  • HC Wainwright reiterated a Buy rating and $290 price target on Axsome Therapeutics, signaling continued upside potential despite recent estimate cuts.
  • Axsome announced support for Mental Health Month and shared resources tied to its CNS-focused mission, reinforcing the company’s brand and patient advocacy position. Axsome Therapeutics Recognizes Mental Health Month
  • Recent articles debated whether Axsome’s stock is starting to look fully valued after its sharp advance, suggesting the market may be reassessing how much growth is already priced in.
  • Coverage also noted that the company’s story is evolving around Auvelity and AXS-05 developments, which could matter longer term but did not include a specific new catalyst in the headlines provided.
  • HC Wainwright made a series of earnings estimate adjustments for fiscal 2026 and 2027, including cuts to several near- and medium-term quarters. While the firm kept a Buy rating, the revisions may have tempered enthusiasm around the speed of profitability.
  • Analysts lowered near-term EPS estimates for Q2 2026, Q3 2026, Q1 2027, Q2 2027, Q3 2027, Q4 2027 and FY2026/FY2027, highlighting slower expected earnings progress than previously forecast.
  • Other broker notes mentioned Hold coverage from Morgan Stanley, which may add to the view that upside is less certain after the stock’s rally.

Overall, AXSM appears to be pulling back as investors digest valuation concerns and analyst estimate revisions, even though Wall Street remains broadly constructive on the long-term pipeline.

Recent News